Damage a structure in the brain, and see what happens as a result.
Research Methods
Measuring Activity
EEG
Used to measure electrical activity - measures electrical potentials on scalp. You just put on a helmet thingy. Very high temporal resolution - but very low spatial resolution (limited to neurons close to scalp and same orientation).
CAT
Uses X-Rays to provide good spacial resolution on brain structure, but gives no insight on brain activity.
fMRI
Measures neuronal activity by measuring blood oxygenation
High spatial resolution, low temporal resolution (signal peaks after 4-6 secs)
Non-invasive, but expensive
PET
Same as fMRI, except more invasive (radioactive tracers injected).
NO TEMPORAL RESOLUTION!
fMRI much better..
TMS
Temporarily excite or inhibit groups groups of neurons close to scalp.
But unclear how it works and can cause epileptic seizures
Balance:
Spacial (image quality) vs. temporal (time of occurence) resolution
Single Neuron electrophysiology
Very high temporal and spatial resolution
However, requires you to insert electrodes on brain - very invasive and rarely possible