EGFR
Tyrosine Kinase Inhibitors
Inhibits EGFR
Current treatment:
Patients gain resistance
HSP90
Stabilizes EGFR
Important for survival and proliferation of EGFR dependent cancers
ErbB2
HSP90 stabilizes independent of EGFR

geldanamycin (GA) and AT13387 

Inhibit HSP90

When HSP90 inhibited, half life of WT-EGFR decreases
Disruptin
blocks binding of HSP90 to EGFR
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