Protein Synthesis Inhibitors
30S subunit
50S subunit
Tetracyclines
Aminoglycosides
Chloramphenicol
Macrolides
Clindamycin
Streptogramins
Linezolid
tRNA acceptor site
  • blocks access of amino acyl-tRNA to acceptor site
  • prevents addition of amino acids to growing peptides
Interferes with initiation complex
  • induce misreading
  • incorporation of incorrect amino acids into growing peptide
  • bactericidal
Blocks synthesis
  • inhibits peptidyl transferase (formation of peptide bond between amino acids)
Inhibits Translocation
Inhibits Peptide formation
Inhibits Initiation
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