Follicular cells
Round nuclei • Inconspicuous nucleoli • Moderate amount of cytoplasm  
Colloid
• May be geometric or cracked, Swiss cheese, bubble gum (thick, dense in papillary carcinoma)
Benign entities
Description
Malignant
Description
Normal structure
• Low cellularity • Small monolayered, honeycombed sheets of evenly distributed follicular cells and single cells • Colloid in the background • +/- Macrophages
Thyroid
Hurthle cells
• Round nuclei • May have conspicuous central nucleoli • Abundant amounts of granular cytoplasm
Cysts
Draining thyroid cyst – therapeutic and diagnostic  
Colloid nodules
Abundant thin colloid with scattered small groups of follicular cells
Papillary carcinoma
• Cellular
• Little or no colloid in the background (colloid may appear as dense, globular, bubble gumlike – uncommon feature)
• Cells arranged in papillary, monolayer tissue fragments, clusters or dispersed as single cells
• Well-formed papillary clusters that appear as 3-D finger-like  
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