Microglia
Basic inforamation (Lec 3) 
Derived from embryonic yolk sac

Labeled by:
- CD11B
- Iba+
- CX3CR1
- Purinergic Receptors
- CSF1
    
Roles (Lec 3) 
"Surveying":
1) Immune sensing - CVOs
2) Maintain structure - BBB, ECM
3) Neuronal - synaptic pruning

"Activated":
1) Cytokine production
2) Complement system activation
3) Reactive mediators
State - M1 
Classical activated microglia
Cytokines involved:
- IL1B, TNF-a, IL-6

State - M2     
Alternate states     
SubState - M2a 
Alternate activation

Cytokines/Molecules:
Arginase, mannose receptor, Ym-1    
Substate - M2b 
Inflammatory and homeostatic

Cytokines:
IL-1, IL-10    
Substate - M2c 
Classical deactivation
Cytokines:
IL-10, IL-4, SOCS    
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