Osteomalacia may show signs as diffuse body pains, muscle weakness, and fragility of the bones.

Description

Need 4000 IU of vit D from all sources

2000 IU of vit D supplement will raise 25(OH)D by about 35 nMoles/L

vit D₃ is better than vit D₂

No taxicity below 30,000 IU of vit D intake per day

Due to external causes

Due to nutrient deficiency

Mal-absorption of Calcium & Phosphrous

Genomic signaling?

Rickets & Osteomalalica (100 iu per day is sufficient to prevent rickets)

Osteoporosis

Falls, immune disorders

Cancer, diabetes

Nutritional labels on foods report minimum required daily amounts to prevent the short latency type diseases; and not necessarily the long latency type diseases and optimal amounts for healthy living.

All tissues need all nutrients

Shortages impair the functioning of all body systems

Organism will work perfectly well without maintenance - for a while ...

Premature organ/system wearing out, as a consequence of nutrient deficiency, will vary from person to person, depending on variable genetic composition; and

therefore, expression of nutrient deficiency will usually be pluriform (not just short latency diseases)

Serum total 25(OH)D - 25 hydroxyD is the functional indicator for vit D status

80 nano Moles/Liter (or 32 nano grams/mL) will be sufficient for maximum absorption of Calcium

Higher levels of 25(OH)D do not increase calcium uptake

25(OH)D Levels:
25 or lower -- deficiency
25 to 80 -- insufficiency
80 to 150 -- normal

If vit D is insufficient, body increases serum iPTH (parathyroid hormone) to increase uptake of calcium for a given serum 25(OH)D